Your Lung Research Needs Physiologically Relevant Models
ATS 2021 Virtual Conference Exhibition
As pulmonary research progresses, you can stay up to date on the latest advances by listening to experts discuss their research, learning about new products/services, and connecting with peers online. Whether you’re attending ATS 2021 virtually from May 14 - 19 or just want to see what’s new in pulmonary research, explore these curated tools and resources to help you model the human lung in vitro, including protocols and webinars on lung organoids and air-liquid interface (ALI) cultures.
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Human lung organoids, in vitro model systems that mimic the in vivo lung, are a powerful tool for studying lung biology, modeling disease, and rapidly developing treatments against respiratory pathogens. Learn how and why you should incorporate this organoid culture system in your research by browsing the resources below.
Pulmonary Organoids Learning Center
Learn about using an organoid culture system for in vitro lung modeling in this collection of protocols, webinars, and other scientific resources.
Experts agree that to fully realize the utility of organoids a certain level of standardization is needed both within and between labs. Gain key insights from their discussions and watch the presentations from our Nature Research Round Table.
Model the Human Airway at the Air-Liquid Interface
Primary human bronchial epithelial cells (HBECs) can be expanded and differentiated at the ALI to obtain a pseudostratified mucociliary epithelium that closely mimics what is observed in vivo. Watch the following protocol videos to learn how you can culture HBECs at the ALI and find helpful resources for their characterization below.
ALI Culture Protocol
Get an overview of the ALI culture workflow in this introductory video, or dive right into the step-by-step protocols by following the links below.
Technological advances have enabled researchers to study cystic fibrosis (CF) using specialized in vitro cell culture models, such as ALI cultures of primary human airway epithelial cells. Learn more about studying CF with airway epithelial cells by exploring the resources below.
Studying Cystic Fibrosis with ALI Cultures
See the side-by-side performance data for different commercially available expansion and differentiation media for culturing CF airway epithelial cells at the ALI.
Researchers considering three-dimensional (3D) models can also use patient-derived organoids to study CF. Airway organoids cultured using PneumaCult™ Airway Organoid Kit demonstrate suitability for monitoring cystic fibrosis transmembrane conductance regulator (CFTR) function using the forskolin-induced swelling assay. See the data >
ATS 2021 Virtual: Prize Draw
We hope you enjoyed ATS 2021! This contest is now closed.
Study COVID-19 with ALI Cultures
Studying how viruses infect the airway tissue tissues helps researchers understand how to intervene and treat infected patients. To date, the ALI culture system has been used to study a wide range of pathogens, including the SARS-CoV-2 virus.
Learn how and why researchers are using ALI cultures to study respiratory viral infections, including COVID-19.
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