Derived from the ventral foregut endoderm, the pancreas is composed of an exocrine compartment that functions primarily to produce and secrete digestive enzymes and an endocrine compartment that functions to regulate glucose homeostasis. When grown with the appropriate signals, proliferative pancreatic cells form organoids representative of the pancreatic exocrine system, which can be maintained and manipulated in vitro. Differentiation of human embryonic or induced pluripotent stem (ES/iPS) cells provide an additional model for studying pancreatic development and disease.

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