Dibutyryl-cAMP

cAMP pathway activator; Activates cAMP-dependent protein kinases

Dibutyryl-cAMP

cAMP pathway activator; Activates cAMP-dependent protein kinases

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cAMP pathway activator; Activates cAMP-dependent protein kinases
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Overview

Dibutyryl-cAMP is a cell-permeable cyclic AMP (cAMP) analog that activates cAMP-dependent protein kinases (Schwede et al.). This product is supplied as the sodium salt of the molecule.


DIFFERENTIATION
· Suppresses experimental autoimmune encephalomyelitis development by reducing demyelination and mobilizing neural stem cells in the subventricular zone towards the demyelinated plaques (Khezri et al.).

· Induces intrinsic axon growth in peripheral and central nervous systems, and morphological differentiation of astrocytes (Knott et al.; Imamura & Ozawa).

· Stimulates neurite outgrowth in PC12 cells (Maruoka et al.).
Cell Type
Astrocytes, Neural Cells, PSC-Derived, Neurons
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Differentiation, Expansion
Area of Interest
Disease Modeling, Neuroscience
CAS Number
16980-89-5
Chemical Formula
C₁₈H₂₃N₅O₈P · Na
Purity
≥ 95%
Pathway
cAMP
Target
cAMP-Dependent Kinase

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
73886, 73882, 73884, 100-0244
Lot #
Lot# 1000056507 or lower for 73882 | Lot# 1000058871 or lower for 73884 | Lot# 1000051758 or lower for 73886 | Lot# 1000045281 or lower for 100-0244
Language
English
Catalog #
73886, 73882, 73884, 100-0244
Lot #
Lot# 1000056508 or higher for 73882 | Lot# 1000058872 or higher for 73884 | Lot# 1000051759 or higher for 73886 | Lot# 1000045282 or higher for 100-0244
Language
English
Document Type
Safety Data Sheet
Catalog #
73886, 73882, 73884
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-0244
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.