Register: Webinar on Neuroimmune Models for Alzheimer’s Risk
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Learn about recent research characterizing potential roles of Alzheimer’s risk gene TREM2 in activating immune responses in the brain.
“Modeling Alzheimer's risk using human TREM2-knockout microglia”
DATE & TIMEThere are multiple sessions for this global event - Please choose the one that best fits your local time of day.
Tuesday, January 26, 2021
Session 1: 9:00 a.m. PST | 12:00 p.m. EST | 6:00 p.m. CET
Tuesday, January 26, 2021
Session 2: 6:00 p.m. PST (Please note that this is Wednesday, January 27, 10:00 a.m. China Standard Time | 11:00 a.m. JST | 12:00 p.m. AEST)
ABSTRACT
Unbiased studies of Alzheimer's disease risk loci have revealed a strong enrichment for loci proposed to affect immune function. At the forefront of these new risk loci is Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). Loss of function of TREM2 increases Alzheimer’s disease risk, though the mechanism for this increased risk is not completely understood. We have modeled TREM2 loss of function through isogenic CRISPR-knockout of TREM2 in iPS-derived human microglia. Through a combination of in vitro mechanistic studies and xenotransplantation into a chimeric model of Alzheimer's disease, we show that human TREM2-knockout microglia fail to properly activate towards disease pathology, suggesting a mechanism for increased risk of Alzheimer's disease.
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University of California, Irvine